Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents
Copyright policy )Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents
The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned 5-HT1A receptor agonists. Only the 8-OH-DPAT-induced decrease of such an effect could be blocked by the postsynaptic antagonist of the 5-HT1A receptor 1-(2-methoxyphenyl)-4-[(4-succinimido)butyl]-piperazine (MM-77). Stressing by forced swimming seems to induce plastic changes in 5-HT1A receptors, which in turn modify the behavioural actions of 5-HT1A receptor agents.
Male, 8-Hydroxy-2-(di-n-propylamino)tetralin, Behavior, Animal, Succinimides, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT1 Receptor Antagonists, Buspirone, Piperazines, Serotonin Receptor Agonists, 5-Methoxytryptamine, Mice, Serotonin Agents, Anti-Anxiety Agents, Receptor, Serotonin, 5-HT1A, Synapses, Exploratory Behavior, Animals, Stress, Psychological, Swimming
Male, 8-Hydroxy-2-(di-n-propylamino)tetralin, Behavior, Animal, Succinimides, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT1 Receptor Antagonists, Buspirone, Piperazines, Serotonin Receptor Agonists, 5-Methoxytryptamine, Mice, Serotonin Agents, Anti-Anxiety Agents, Receptor, Serotonin, 5-HT1A, Synapses, Exploratory Behavior, Animals, Stress, Psychological, Swimming
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