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Physica Medica
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Physica Medica
Article . 2018 . Peer-reviewed
License: Elsevier TDM
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[P108] Radiation safety after 177Lu-dota-tate therapy for neuroendocrine tumors

Authors: Josep María Martí-Climent; Elena Prieto; Verónica Morán; Pedro Borja Aguilar; María I. Morales-Lozano; Javier Arbizu;

[P108] Radiation safety after 177Lu-dota-tate therapy for neuroendocrine tumors

Abstract

Purpose To evaluate the safety of peptide receptors radionuclide therapy (PRRT) of neuroendocrine tumors after 7.4 GBq 177Lu-DOTA-TATE by measurement of the radiation exposure rates. Methods For each patient the radiation levels (H∗(10)) were measured at 1 meter distance from the patient abdomen. Measurements were performed with a survey meter at different time points, over 4 days from the treatment administration of a prescribed activity of 7.4 GBq of 177Lu-DOTA-TATE. The first measure was accomplished at the end of the 177Lu-octreotate infusion and before voiding of bladder, while the others were done after emptied the bladder. Results 13 patients (36 cycles) were treated with a mean (standard deviation) activity of 6834 (688) MBq per cycle. Mean (maximum) dose rates measured at 1, 8, 24, 48 and 97 h (mean time) after treatment initiation were 32 (42), 15 (27), 9 (19) 7 (18) and 5 (11) μ Sv/h, respectively. At 8, 24, 48 and 97 h, 90% of the patients radiation levels were below 20, 16, 12 and 8.4 μ Sv/h, respectively. In relation to the first measurement, the mean uptakes were 47, 31, 24 and 16%. Considering the physical decay of the isotope, the dose limits for individual members of the public and an 8 h a day permanence at 1 m of the patient, the maximum dose rate allowed for patient release would be 13 μ Sv/h. Conclusions Taking into account the dose rates at 1 meter and the analysis of the specific conditions of the family and social environment of each patient, after 24 h of the treatment administration the patient can be released in 75% of cases.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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Average
bronze