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European Journal of Control
Article . 2016 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Article . 2016
Data sources: zbMATH Open
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Article . 2020
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Tradeoffs in adapting biological systems

Authors: Rajat Bhatnagar; Hana El-Samad;

Tradeoffs in adapting biological systems

Abstract

Biological systems must sense and adapt to changes in their environment. Molecular networks capable of such adaptation belong to two well-known classes, feed-forward and feedback structures, but the fundamental limitations and tradeoffs of these two classes remain unknown. Here we study the advantages and limitations of the feedforward class using three-node circuits representative of these architectures. The feedforward model we investigate displays a tradeoff between the sensitivity of the response (its peak response) and its precision (its error in its return to steady-state). We suggest two ways in which this tradeoff can be alleviated: (1) by introducing a nonlinearity in the production of a specific node in the network, or (2) by adding a feedback loop to the input. We present analytical and numerical examples to support our findings.

Related Organizations
Keywords

Adaptive control/observation systems, Systems biology, networks, perfectly adapting systems, biological control

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
bronze