Anchored cAMP signaling: Onward and upward – A short history of compartmentalized cAMP signal transduction
Copyright policy )Anchored cAMP signaling: Onward and upward – A short history of compartmentalized cAMP signal transduction
Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase anchoring proteins (AKAPs). This review discusses the history and future of anchored cAMP signaling pathways.
- Vollum Institute United States
- Howard Hughes Medical Institute United States
- Oregon Health & Science University United States
Cyclic AMP, Animals, History, 20th Century, History, 21st Century, Models, Biological, Adaptor Proteins, Signal Transducing, Cell Compartmentation, Signal Transduction
Cyclic AMP, Animals, History, 20th Century, History, 21st Century, Models, Biological, Adaptor Proteins, Signal Transducing, Cell Compartmentation, Signal Transduction
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