Cancer CXC chemokine networks and tumour angiogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2006 English Publisher:Elsevier BVJournal:European Journal of Cancer, volume 42, pages 768-778 (issn: 0959-8049,

Copyright policy )

Authors: Robert M, Strieter; Marie D, Burdick; Javier, Mestas; Brigitte, Gomperts; Michael P, Keane; John A, Belperio;

doi: 10.1016/j.ejca.2006.01.006

pmid: 16510280

Cancer CXC chemokine networks and tumour angiogenesis

- Summary
- Subjects
- Metrics

Abstract

Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The glutamic acid-leucine-arginine (ELR+) CXC chemokines are potent promoters of angiogenesis, and mediate their angiogenic activity via signal-coupling of CXCR2 on endothelium. By contrast, members of the CXC chemokine family, such as platelet factor-4 (PF4; CXCL4) and interferon-inducible CXC chemokines are potent inhibitors of angiogenesis, and use CXCR3 on endothelium to mediate their angiostatic activity. This review will discuss the biology of CXC chemokines in the context of angiogenesis related to cancer.

Related Organizations

University of California, Los Angeles
United States

Keywords

Immunity, Cellular, Neovascularization, Pathologic, Neoplasms, Angiostatic Proteins, Humans, Angiogenesis Inhibitors, Chemokines, CXC

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	387
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%