An open multicentre comparative study of the efficacy, safety and tolerance of fluconazole and itraconazole in the treatment of cancer patients with oropharyngeal candidiasis
Copyright policy )An open multicentre comparative study of the efficacy, safety and tolerance of fluconazole and itraconazole in the treatment of cancer patients with oropharyngeal candidiasis
Oropharyngeal candidiasis is a frequent infection in cancer patients who receive cytotoxic drugs. In this study, the efficacy, safety and tolerance of fluconazole and itraconazole were compared in non-neutropenic cancer patients with oropharyngeal candidiasis. Of 279 patients who were randomised between the two treatment groups, 252 patients were considered to be eligible (126 in each group). The clinical cure rate was 74% for fluconazole and 62% for itraconazole (P=0.04, 95% Confidence Interval (CI): 0.5-23.3%). The mycological cure rate was 80% for fluconazole and 68% for itraconazole (P=0.03, 95% CI: 1.2-22.6%). The safety and tolerance profile of both drugs were comparable. This study has shown that in patients with cancer and oropharyngeal candidiasis, fluconazole has a significantly better clinical and mycological cure rate compared with itraconazole.
- Hammersmith Hospital United Kingdom
- Radboud University Nijmegen Netherlands
- Hacettepe University Turkey
- Radboud University Nijmegen Medical Centre Netherlands
- Imperial College Healthcare NHS Trust United Kingdom
Adult, Male, Antifungal Agents, Adolescent, Candida glabrata, Middle Aged, Immunocompromised Host, EBP 3: Effective Primary Care and Public Health, UMCN 1.5: Interventional oncology, Liver, Liver Function Tests, Candidiasis, Oral, Neoplasms, Candida albicans, Humans, UMCN 4.1: Microbial pathogenesis and host defense, Female, Itraconazole, Fluconazole, Aged
Adult, Male, Antifungal Agents, Adolescent, Candida glabrata, Middle Aged, Immunocompromised Host, EBP 3: Effective Primary Care and Public Health, UMCN 1.5: Interventional oncology, Liver, Liver Function Tests, Candidiasis, Oral, Neoplasms, Candida albicans, Humans, UMCN 4.1: Microbial pathogenesis and host defense, Female, Itraconazole, Fluconazole, Aged
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