Detection of cervical precancer and cancer in a hospital population
Copyright policy )Detection of cervical precancer and cancer in a hospital population
The aim was to determine the relevance of human papillomavirus (HPV) testing in identifying high-grade cervical intraepithelial neoplasia or worse (CIN2/3+) in a hospital population (n=3574) characterised by a high rate of cytological abnormalities and high-risk HPV infections. According to the results of the initial Papanicolaou and HPV test, women were directly referred for colposcopy/biopsy or recalled for a control visit. Sensitivity and specificity were corrected for verification bias. HPV-testing sensitivity was 94.3%, higher than that of cytological testing at any cut-off point (65.1%-86.8%), while specificity was greater for cytology than for HPV testing (99.3% or 91.8% versus 83.4%). The combination of both tests allowed 100% sensitivity and negative predictive value. We conclude that HPV testing is a relevant tool for the detection of cervical disease. The best way of combining cytology and HPV detection in screening programmes should be evaluated in large-scale studies.
Uterine Cervical Neoplasms, MESH: Hospitalization, MESH: Papillomavirus Infections, MESH: Papillomaviridae, 80 and over, Mass Screening, Viral, Papillomaviridae, MESH: Aged, Aged, 80 and over, MESH: Middle Aged, MESH: DNA, MESH: Follow-Up Studies, Middle Aged, MESH: Uterine Cervical Neoplasms, Hospitalization, MESH: Precancerous Conditions, Colposcopy, MESH: Colposcopy, Female, Papanicolaou Test, Adult, MESH: Vaginal Smears, Adolescent, 610, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Papanicolaou Test, Sensitivity and Specificity, 618, [SDV.CAN] Life Sciences [q-bio]/Cancer, Humans, MESH: Mass Screening, Cervical Intraepithelial Neoplasia, Aged, MESH: Adolescent, Vaginal Smears, MESH: Humans, Papillomavirus Infections, MESH: Tumor Virus Infections, MESH: Adult, MESH: Sensitivity and Specificity, Tumor Virus Infections, DNA, Viral, MESH: Cervical Intraepithelial Neoplasia, MESH: Female, Precancerous Conditions, Follow-Up Studies
Uterine Cervical Neoplasms, MESH: Hospitalization, MESH: Papillomavirus Infections, MESH: Papillomaviridae, 80 and over, Mass Screening, Viral, Papillomaviridae, MESH: Aged, Aged, 80 and over, MESH: Middle Aged, MESH: DNA, MESH: Follow-Up Studies, Middle Aged, MESH: Uterine Cervical Neoplasms, Hospitalization, MESH: Precancerous Conditions, Colposcopy, MESH: Colposcopy, Female, Papanicolaou Test, Adult, MESH: Vaginal Smears, Adolescent, 610, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Papanicolaou Test, Sensitivity and Specificity, 618, [SDV.CAN] Life Sciences [q-bio]/Cancer, Humans, MESH: Mass Screening, Cervical Intraepithelial Neoplasia, Aged, MESH: Adolescent, Vaginal Smears, MESH: Humans, Papillomavirus Infections, MESH: Tumor Virus Infections, MESH: Adult, MESH: Sensitivity and Specificity, Tumor Virus Infections, DNA, Viral, MESH: Cervical Intraepithelial Neoplasia, MESH: Female, Precancerous Conditions, Follow-Up Studies
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