Age-Associated Abnormalities of Water Homeostasis
Copyright policy )Age-Associated Abnormalities of Water Homeostasis
Findley first proposed the presence of age-related dysfunction of the hypothalamic-neurohypophyseal-renal axis more than 60 years ago. More sophisticated studies have since corroborated his findings. As a result, it is now clear that multiple abnormalities in water homeostasis occur commonly with aging, and that the elderly are uniquely susceptible to disorders of body volume and osmolality. This article summarizes the distinct points along the hypothalamic-neurohypophyseal-renal axis where these changes have been characterized, as well as the clinical significance of these changes, with special attention to effects on cognition, gait instability, osteoporosis, fractures, and morbidity and mortality.
- University of Pittsburgh United States
- University of Pittsburgh Medical Center United States
- New York University United States
- University of Washington Medical Center United States
- Georgetown University Medical Center United States
Risk, Aging, Hypothalamo-Hypophyseal System, Water-Electrolyte Imbalance, Water, Water-Electrolyte Balance, Kidney, Severity of Illness Index, Arginine Vasopressin, Inappropriate ADH Syndrome, Kidney Concentrating Ability, Pituitary Gland, Posterior, Homeostasis, Animals, Humans, Renal Insufficiency, Thirst, Aged, Hyponatremia
Risk, Aging, Hypothalamo-Hypophyseal System, Water-Electrolyte Imbalance, Water, Water-Electrolyte Balance, Kidney, Severity of Illness Index, Arginine Vasopressin, Inappropriate ADH Syndrome, Kidney Concentrating Ability, Pituitary Gland, Posterior, Homeostasis, Animals, Humans, Renal Insufficiency, Thirst, Aged, Hyponatremia
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