Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Recolector de Cienci...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Recolector de Ciencia Abierta, RECOLECTA
Article . 2012 . Peer-reviewed
Data sources: Recolector de Ciencia Abierta, RECOLECTA
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Endocrinology and Metabolism Clinics of North America
Article . 2012 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Recolector de Ciencia Abierta, RECOLECTA
Article . 2012 . Peer-reviewed
Data sources: Recolector de Ciencia Abierta, RECOLECTA
https://pubmed.ncbi.nlm.nih.go...
Article . 2012
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.e...
Article
Data sources: Microsoft Academic Graph
https://dx.doi.org/10.1016/j.e...
Article
Data sources: Microsoft Academic Graph
 View all 3 versions
Claim

Insulin-Like Growth Factor-1 and Central Neurodegenerative Diseases

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2012 English Publisher:Elsevier BVJournal:Endocrinology and Metabolism Clinics of North America, volume 41, pages 395-408 (issn: 0889-8529, Copyright policy )
Authors: Torres Alemán, Ignacio;

doi: 10.1016/j.ecl.2012.04.016

pmid: 22682637

handle: 10261/59612

Insulin-Like Growth Factor-1 and Central Neurodegenerative Diseases

Abstract

The previously undisputed neuroprotective role of insulin-like growth factor 1 (IGF-1) has been challenged by recent observations in IGF-1 receptor (IGF-1R) defective mutants. As new ligand-dependent and ligand-independent roles for IGF-1R are now emerging, new insights into the biologic role of brain IGF-1R and its connection with serum and brain IGF-1 function are urgently required. In the meantime, treatment of specific neurodegenerative diseases with IGF-1 may still be explored using adequate preclinical procedures.

Related Organizations
Keywords

Inflammation, Aging, Neurodegenerative Diseases, Endoplasmic Reticulum Stress, Rats, Receptor, IGF Type 1, Mice, Oxidative Stress, Central Nervous System Diseases, Autophagy, Unfolded Protein Response, Animals, Humans, Insulin-Like Growth Factor I

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 37
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
    OpenAIRE UsageCounts
    Usage byUsageCounts
    visibility views 28
    download downloads 11
  • 28
    views
    11
    downloads
    Powered byOpenAIRE UsageCounts
Powered by OpenAIRE graph
Found an issue? Give us feedback
visibility
download
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
37
Top 10%
Top 10%
Top 10%
28
11
Green
Related to Research communities
Knowmad Institut