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Molecular mechanisms of external genitalia development

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2012 United States Publisher:Elsevier BVJournal:Differentiation, volume 84, pages 261-268 (issn: 0301-4681,

Authors: Blaschko, Sarah D; Cunha, Gerald R; Baskin, Laurence S;

doi: 10.1016/j.diff.2012.06.003

pmid: 22790208

pmc: PMC3443292

Molecular mechanisms of external genitalia development

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Abstract

External genitalia development occurs through a combination of hormone independent, hormone dependent, and endocrine pathways. Perturbation of these pathways can lead to abnormal external genitalia development. We review human and animal mechanisms of normal and abnormal external genitalia development, and we evaluate abnormal mechanisms that lead to hypospadias. We also discuss recent laboratory findings that further our understanding of animal models of hypospadias.

Country

United States

Related Organizations

University of California, Berkeley
United States
University of California, San Francisco
United States
University of California System
United States

Keywords

Urologic Diseases, Male, Sex Differentiation, Development, Paediatrics and Reproductive Medicine, Pregnancy, Animals, Humans, Developmental, Genes, Developmental, Genitalia, Gonadal Steroid Hormones, Hypospadias, Biological Sciences, Sex Determination Processes, Genes, Biochemistry and cell biology, Prenatal Exposure Delayed Effects, External genitalia, Female, Biochemistry and Cell Biology, Developmental Biology

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	115
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%