The Wnt/β-catenin signaling pathway plays important roles in embryonic development and disease. Wnts transduce signals via transmembrane receptors of the Frizzled (Fzd) family and the low density lipoprotein receptor-related protein 5/6 (Lrp5/6). A key mechanism in their signal transduction is that Wnts induce Lrp6 signalosomes, which become phosphorylated at multiple conserved sites. Lrp6 phosphorylation is crucial to beta-catenin stabilization and pathway activation by promoting Axin and Gsk3 recruitment. I will discuss the regulation of this co-receptor and the significance for Xenopus early development.