Updated dataset based on the laser scanning of three specimens of lunar soil simulants representing highland regions (LHS-1, AGK-2010, CHENOBI) and three specimens of lunar soil simulants representing mare regions (LMS-1, JSC-1A, OPRL2N). In previous studies, only a specimen of ilmenite was used as a lunar soil simulants. Measurements were executed using phase-shift and time-of-fly terrestrial laser scanners (Z + F IMAGER 5016, FARO Focus3D, and Leica ScanStation C10). The stored data contain radiometric information of point clouds from the measurement of lunar soil simulants. The data provide information on the effect of different types of simulants (mare and highland) on the absorption and dispersion of the laser beam. In overall, the dataset presented in this work can be used in investigation of the application of the laser technology in the measurement of lunar structures made of mare and highlands lunar regolith. Lunar highlands and mare regions are characterized by different physicochemical parameters. Therefore, both types of soil scatter the laser beam differently, what affects the range and accuracy of the laser measurements.