TfR in focus: Orchestrating autophagosome biogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2025 English Publisher:Elsevier BVJournal:Developmental Cell, volume 60, pages 2,697-2,699 (issn: 1534-5807,

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Authors: Yan G, Zhao; Hong, Zhang;

doi: 10.1016/j.devcel.2025.09.008

pmid: 41118746

TfR in focus: Orchestrating autophagosome biogenesis

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Abstract

Transferrin receptors, responsible for iron importation into cells, exhibit additional iron-independent functions. In this issue, Puri et al. reveal that the transferrin receptor recruits the VPS34 complex I, stimulating PI(3)P synthesis. This PI(3)P production aids in autophagosome elongation and closure by facilitating recruitment of the LC3 conjugation system and ESCRT, respectively.

Related Organizations

Southern University of Science and Technology
China (People's Republic of)
Chinese Academy of Sciences
China (People's Republic of)
University of Chinese Academy of Sciences
China (People's Republic of)
Institute of Biophysics
China (People's Republic of)
State Key Laboratory of Biomacromolecules
China (People's Republic of)

Keywords

Endosomal Sorting Complexes Required for Transport, Iron, Receptors, Transferrin, Autophagosomes, Autophagy, Humans, Animals, Class III Phosphatidylinositol 3-Kinases

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