Major construction entails major demolition

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2022 Netherlands English Publisher:Elsevier BVJournal:Developmental Cell, volume 57, pages 1,311-1,313 (issn: 1534-5807,

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Authors: Korotkevich, Ekaterina; Hiiragi, Takashi;

doi: 10.1016/j.devcel.2022.05.008

pmid: 35671703

handle: 20.500.11755/44d68fdd-bff3-482d-bcb0-96accc4ec1a3

Major construction entails major demolition

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Abstract

Embryonic cells of the early mouse embryo become hypersensitive to apoptotic stimuli before gastrulation. In this issue of Developmental Cell, Pernaute et al. show that this switch in sensitivity is a result of a change in mitochondrial dynamics and mitophagy levels controlled by DRP1, a regulator of mitochondrial fission.

Country

Netherlands

Related Organizations

Royal Netherlands Academy of Arts and Sciences (KNAW)
Netherlands
Royal Netherlands Academy of Arts and Sciences
Netherlands
Hubrecht Institute for Developmental Biology and Stem Cell Research
Netherlands
Kyoto University
Japan

Keywords

Dynamins, Mitochondrial Proteins, Mice, Mitophagy, Animals, Mitochondrial Dynamics

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