How NPC1 Loss Twists the TORCque of Lysosomes

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2021 English Publisher:Elsevier BVJournal:Developmental Cell, volume 56, pages 251-252 (issn: 1534-5807,

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Authors: W Mike, Henne;

doi: 10.1016/j.devcel.2021.01.007

pmid: 33561418

How NPC1 Loss Twists the TORCque of Lysosomes

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Abstract

Niemann-Pick type C is a neurological disorder caused by mutations in the lysosome cholesterol exporter NPC1. In this issue of Developmental Cell, Davis et al. dissect how NPC1 loss elevates mTORC1 signaling, and demonstrate that suppression of mTORC1 signaling can rescue disease pathology in NPC1-deficient cell models.

Related Organizations

The University of Texas Southwestern Medical Center
United States

Keywords

Cholesterol, Niemann-Pick C1 Protein, Intracellular Signaling Peptides and Proteins, Humans, Lysosomes, Signal Transduction

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