Cells under Tension Drive Gastrulation

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2020 English Publisher:Elsevier BVJournal:Developmental Cell, volume 55, pages 669-670 (issn: 1534-5807,

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Authors: Clayton, Schwarz; Anna-Katerina, Hadjantonakis;

doi: 10.1016/j.devcel.2020.11.023

pmid: 33352138

Cells under Tension Drive Gastrulation

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Abstract

In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing stem cells in embryo-like mechanical environments.

Related Organizations

Rockefeller University
United States
Memorial Sloan Kettering Cancer Center
United States

Keywords

Mesoderm, Pluripotent Stem Cells, Gastrulation, Human Embryonic Stem Cells, Humans, Cell Differentiation, beta Catenin

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