MTORC1 and the Rebirth of Stemness

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2020 English Publisher:Elsevier BVJournal:Developmental Cell, volume 55, pages 113-115 (issn: 1534-5807,

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Authors: Nicolette M, Johnson; Christopher J, Lengner;

doi: 10.1016/j.devcel.2020.10.001

pmid: 33108751

MTORC1 and the Rebirth of Stemness

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Abstract

MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.

Related Organizations

University of Pennsylvania
United States
Yazd University
Iran (Islamic Republic of)
Sai University
India

Keywords

Extracellular Vesicles, Stem Cells, Tumor Microenvironment, Mechanistic Target of Rapamycin Complex 1, Mitochondrial Dynamics

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