Linking Matrix Rigidity with EMT and Cancer Invasion

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2020 English Publisher:Elsevier BVJournal:Developmental Cell, volume 54, pages 293-295 (issn: 1534-5807,

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Authors: Manon, Ros; Margaux, Sala; Frédéric, Saltel;

doi: 10.1016/j.devcel.2020.06.032

pmid: 32781020

Linking Matrix Rigidity with EMT and Cancer Invasion

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Abstract

The extracellular matrix (ECM) plays a major role in cancer progression through its increased deposition and alignment. In this issue of Developmental Cell, Fattet et al. reveal a pathway in which ECM stiffness promotes EPHA2/LYN complex activation, leading to TWIST1 nuclear localization and triggering EMT in breast cancer.

Related Organizations

University of Bordeaux
France
French Institute of Health and Medical Research
France
University of Bordeaux
France

Keywords

Epithelial-Mesenchymal Transition, Twist-Related Protein 1, Humans, Breast Neoplasms, Extracellular Matrix

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