Pyroptosis Takes Aim at Neurodevelopment

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2020 English Publisher:Elsevier BVJournal:Developmental Cell, volume 53, pages 498-499 (issn: 1534-5807,

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Authors: Jaeda C, Coutinho-Budd; Heather T, Broihier;

doi: 10.1016/j.devcel.2020.05.013

pmid: 32516594

Pyroptosis Takes Aim at Neurodevelopment

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Abstract

In a recent issue of Nature, Lammert et al. demonstrate that DNA damage drives AIM2-mediated pyroptosis during normal brain development, preventing anxiety-like behaviors acquisition in adults and revealing an important role for non-apoptotic mechanisms of cell death during neurodevelopment.

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Keywords

DNA-Binding Proteins, Inflammasomes, Caspase 1, Pyroptosis, DNA Damage

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