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Developmental Cell
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Developmental Cell
Article . 2019 . Peer-reviewed
License: Elsevier Non-Commercial
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Article . 2020
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The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2019 English Publisher:Elsevier BVJournal:Developmental Cell, volume 50, pages 525-526 (issn: 1534-5807, Copyright policy )
Authors: Charis L, Himeda; Peter L, Jones;

doi: 10.1016/j.devcel.2019.08.010

pmid: 31505171

The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease

Abstract

In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic program in adult cells.

Related Organizations
Keywords

Homeodomain Proteins, Neoplasms, Humans, Muscular Dystrophy, Facioscapulohumeral, Immune Evasion

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 7
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Average
hybrid
Related to Research communities
Cancer Research