To BBB or Not to BBB?
Copyright policy )To BBB or Not to BBB?
In this issue of Developmental Cell, Anbalagan et al. demonstrate that pituicytes, a subtype of astroglia, drive endothelial cell permeability in the zebrafish embryo neurohypophysis. This occurs via secretion of Vegfa/Tgfβ3 permeability factors that promote formation of fenestrae and the repression of anti-inflammatory retinoic acid signaling that induces tight cell junctions.
- Inserm France
- Yale University United States
- Hôpital Européen Georges-Pompidou France
- Sorbonne University France
- University of Paris France
Pituitary Gland, Posterior, Blood-Brain Barrier, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Animals, Cues, Permeability, Tight Junctions
Pituitary Gland, Posterior, Blood-Brain Barrier, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Animals, Cues, Permeability, Tight Junctions
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