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Developmental Cell
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Developmental Cell
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License: Elsevier Non-Commercial
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Article . 2018
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Instructions for Assembling the Early Mammalian Embryo

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2018 Australia Publisher:Elsevier BVJournal:Developmental Cell, volume 45, pages 667-679 (issn: 1534-5807, Copyright policy )
Authors: White, Melanie D.; Zenker, Jennifer; Bissiere, Stephanie; Plachta, Nicolas;

doi: 10.1016/j.devcel.2018.05.013

pmid: 29920273

Instructions for Assembling the Early Mammalian Embryo

Abstract

The preimplantation mouse embryo is a simple self-contained system, making it an excellent model to discover how mammalian cells function in real time and in vivo. Work over the last decade has revealed some key morphogenetic mechanisms that drive early development, yielding rudimentary instructions for the generation of a mammalian embryo. Here, we review the instructions revealed thus far, and then discuss remaining challenges to discover upstream factors controlling cell fate determination, test the role of mechanisms based on biological noise, and take advantage of recent technological developments to advance the spatial and temporal resolution of our current understanding.

Country
Australia
Related Organizations
Keywords

mouse embryo, 1300 Biochemistry, morphogenesis, preimplantation, Cell Polarity, Embryonic Development, Genetics and Molecular Biology, Cell Differentiation, differentiation, live imaging, Embryo, Mammalian, Models, Biological, 1307 Cell Biology, 1309 Developmental Biology, Mice, Blastocyst, Imaging, Three-Dimensional, 1312 Molecular Biology, Morphogenesis, Animals, polarity, Cell Lineage

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 83
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
83
Top 1%
Top 10%
Top 1%
hybrid