RNA Methylation Clears the Way

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2017 English Publisher:Elsevier BVJournal:Developmental Cell, volume 40, pages 427-428 (issn: 1534-5807,

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Authors: Cassandra, Kontur; Antonio, Giraldez;

doi: 10.1016/j.devcel.2017.02.024

pmid: 28292421

RNA Methylation Clears the Way

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Abstract

During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.

Related Organizations

Yale University
United States
Yale Cancer Center
United States

Keywords

RNA, Messenger, Stored, Zygote, RNA Stability, Gene Expression Regulation, Developmental, RNA, Messenger, Methylation

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