
The first cell fate choice in mouse development is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm. In this issue of Developmental Cell, Korotkevic and colleagues (2017) show that the interplay between cell polarization and cell-cell contact drives the segregation of these lineages, providing a framework for self-organization in development.
570, Science & Technology, Mammalian, FATE, Cell Differentiation, Cell Biology, 06 Biological Sciences, Embryo, Mammalian, Mice, Blastocyst, Embryo, Animals, PREIMPLANTATION EMBRYOS, TROPHECTODERM, CELL, BLASTOMERES, SPECIFICATION, Life Sciences & Biomedicine, 11 Medical and Health Sciences, Developmental Biology, POLARITY
570, Science & Technology, Mammalian, FATE, Cell Differentiation, Cell Biology, 06 Biological Sciences, Embryo, Mammalian, Mice, Blastocyst, Embryo, Animals, PREIMPLANTATION EMBRYOS, TROPHECTODERM, CELL, BLASTOMERES, SPECIFICATION, Life Sciences & Biomedicine, 11 Medical and Health Sciences, Developmental Biology, POLARITY
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