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Metabolic Control of Cellular Differentiation

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2016Publisher:Elsevier BVJournal:Developmental Cell, volume 39, pages 286-287 (issn: 1534-5807,

Authors: Alexander Aulehla; Vinay Bulusu;

doi: 10.1016/j.devcel.2016.10.019

pmid: 27825439

Metabolic Control of Cellular Differentiation

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Abstract

The role of metabolic rewiring during cellular differentiation is under intense investigation. Reporting recently in Science, Peng et al. (2016) found that activation of glycolysis supports T helper cell differentiation by controlling acetyl-coA and histone acetylation levels, identifying a link between metabolic state and epigenetic control of gene activity.

Related Organizations

University of Glasgow
United Kingdom
European Molecular Biology Laboratory
Germany
Cancer Research UK Scotland Institute
United Kingdom

Keywords

Histones, Acetyl Coenzyme A, Acetylation, Cell Differentiation, Protein Processing, Post-Translational

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	8
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average