Krebs Cycle Moonlights in Caspase Regulation

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2016 English Publisher:Elsevier BVJournal:Developmental Cell, volume 37, pages 1-2 (issn: 1534-5807,

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Authors: Adi, Minis; Hermann, Steller;

doi: 10.1016/j.devcel.2016.03.016

pmid: 27046823

pmc: PMC4957690

Krebs Cycle Moonlights in Caspase Regulation

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Abstract

In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation.

Related Organizations

Rockefeller University
United States
Howard Hughes Medical Institute
United States

Keywords

Male, Caspases, Citric Acid Cycle, Animals, Drosophila Proteins, Drosophila, Cullin Proteins, Spermatids, Mitochondria

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