Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins
Copyright policy )Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins
Inhibition of GSK3 by Wnt signaling stabilizes many cellular proteins, but proof that this effect is independent of β-catenin-mediated transcription is lacking. Koch, Acebron, and colleagues (2015) now demonstrate that transcriptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation during their lengthy travels through the epididymis.
- University of California, Los Angeles United States
- University of California United States
Epididymis, Male, Contraception/Reproduction, Biological Sciences, Medical and Health Sciences, Sperm Maturation, Gene Expression Regulation, Genetics, Animals, Wnt Signaling Pathway, Developmental Biology
Epididymis, Male, Contraception/Reproduction, Biological Sciences, Medical and Health Sciences, Sperm Maturation, Gene Expression Regulation, Genetics, Animals, Wnt Signaling Pathway, Developmental Biology
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