A Polyamine Twist on Hedgehog Signaling

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2015 English Publisher:Elsevier BVJournal:Developmental Cell, volume 35, pages 1-2 (issn: 1534-5807,

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Authors: Zhao, Xuesong; Segal, Rosalind A.;

doi: 10.1016/j.devcel.2015.09.024

pmid: 26460938

A Polyamine Twist on Hedgehog Signaling

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Abstract

The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.

Related Organizations

Harvard University
United States
Dana-Farber Cancer Institute
United States

Keywords

Neurons, AMP-Activated Protein Kinases, Ornithine Decarboxylase, Polyamines, Animals, Humans, Female, Hedgehog Proteins, Developmental Biology, Cell Proliferation, Medulloblastoma

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