A Phosphoinositide Code for Primary Cilia

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2015 English Publisher:Elsevier BVJournal:Developmental Cell, volume 34, pages 379-380 (issn: 1534-5807,

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Authors: Nakatsu, Fubito;

doi: 10.1016/j.devcel.2015.08.008

pmid: 26305588

A Phosphoinositide Code for Primary Cilia

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Abstract

How phosphoinositide metabolism is coupled to primary cilia physiology is poorly understood. Reporting recently in Developmental Cell, Chávez et al. (2015) and Garcia-Gonzalo et al. (2015) show that INPP5E-mediated phosphoinositide metabolism, which creates a specific phosphoinositide distribution, ensures proper protein trafficking and Hh signaling in primary cilia.

Related Organizations

Niigata University
Japan

Keywords

Phosphatidylinositol Phosphates, Animals, Proteins, Hedgehog Proteins, Cilia, Phosphoric Monoester Hydrolases, Developmental Biology, Receptors, G-Protein-Coupled

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