A Notch above Sonic Hedgehog

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2015 English Publisher:Elsevier BVJournal:Developmental Cell, volume 33, pages 371-372 (issn: 1534-5807,

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Authors: Yabut, Odessa; Pleasure, Samuel J.; Yoon, Keejung;

doi: 10.1016/j.devcel.2015.05.001

pmid: 26017768

A Notch above Sonic Hedgehog

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Abstract

Cell fate specification requires tightly orchestrated cellular responses to extracellular factors. In this issue of Developmental Cell, Kong et al. (2015) reveal that Notch signaling activity facilitates the interpretation of Sonic hedgehog (Shh) signals by regulating signaling in the cilia, influencing fate specification of neural stem and progenitor cells.

Related Organizations

University of California, San Francisco
United States
Sungkyunkwan University
Korea (Republic of)
Sungkyul University
Korea (Republic of)

Keywords

Neural Stem Cells, Receptors, Notch, Neurogenesis, Stem Cells, Animals, Cell Differentiation, Hedgehog Proteins, Cilia, Developmental Biology

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