Hypo- or Hyper-Hippo: A Balancing Act with bHLH Transcription Factors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2015 English Publisher:Elsevier BVJournal:Developmental Cell, volume 32, pages 133-135 (issn: 1534-5807,

Copyright policy )

Authors: Cook, Tiffany A.;

doi: 10.1016/j.devcel.2015.01.007

pmid: 25625203

pmc: PMC5534332

Hypo- or Hyper-Hippo: A Balancing Act with bHLH Transcription Factors

- Summary
- Subjects
- Metrics

Abstract

Balancing cell growth with differentiation is essential for tissue integrity. In this issue of Developmental Cell, Wang and Baker (2015) demonstrate unsuspected cross-talk between bHLH transcription factors, important regulators of organogenesis, with the Hippo tumor suppressor pathway to ensure that inappropriately differentiating cells are eliminated during development.

Related Organizations

Cincinnati Children's Hospital Medical Center
United States

Keywords

Intracellular Signaling Peptides and Proteins, Hippo Kinases, Cell Cycle Proteins, Cell Cycle Checkpoints, Protein Serine-Threonine Kinases, Drosophila melanogaster, Animals, Drosophila Proteins, Protein Kinases, Developmental Biology, Signal Transduction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	1
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average