Synaptic Vesicle Fusion without SNARE Transmembrane Regions

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2013 English Publisher:Elsevier BVJournal:Developmental Cell, volume 27, pages 124-126 (issn: 1534-5807,

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Authors: Rizo, Josep; Xu, Junjie;

doi: 10.1016/j.devcel.2013.10.010

pmid: 24176637

Synaptic Vesicle Fusion without SNARE Transmembrane Regions

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Abstract

Diverse roles in membrane fusion have been proposed for the transmembrane regions (TMRs) of SNARE proteins, including formation of channel-like transmembrane pores. Reporting in Neuron, Zhou et al. (2013) show that lipid-anchored SNAREs lacking TMRs can support neurotransmitter release, suggesting that SNAREs function primarily as power engines that force membranes together.

Related Organizations

The University of Texas Southwestern Medical Center
United States

Keywords

Membrane Lipids, Neurotransmitter Agents, Animals, Synaptic Vesicles, SNARE Proteins, Membrane Fusion, Synaptic Transmission, Developmental Biology

1 Research products, page 1 of 1

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release
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