Spatial Coordination between Stem Cell Activity and Cell Differentiation in the Root Meristem
Copyright policy )Spatial Coordination between Stem Cell Activity and Cell Differentiation in the Root Meristem
A critical issue in development is the coordination of the activity of stem cell niches with differentiation of their progeny to ensure coherent organ growth. In the plant root, these processes take place at opposite ends of the meristem and must be coordinated with each other at a distance. Here, we show that in Arabidopsis, the gene SCR presides over this spatial coordination. In the organizing center of the root stem cell niche, SCR directly represses the expression of the cytokinin-response transcription factor ARR1, which promotes cell differentiation, controlling auxin production via the ASB1 gene and sustaining stem cell activity. This allows SCR to regulate, via auxin, the level of ARR1 expression in the transition zone where the stem cell progeny leaves the meristem, thus controlling the rate of differentiation. In this way, SCR simultaneously controls stem cell division and differentiation, ensuring coherent root growth.
- Swedish University of Agricultural Sciences Sweden
- University of Parma Italy
- Utrecht University Netherlands
- University of Pavia Italy
- Roma Tre University Italy
570, Cytokinins, root development, growth, Green Fluorescent Proteins, Meristem, Arabidopsis, Models, Biological, Plant/drug effects, arabidopsis root, Models, Gene Expression Regulation, Plant, expression, Stem Cells/cytology, division, thaliana, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Stem Cell Niche, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Arabidopsis; Arabidopsis Proteins; Cytokinins; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Indoleacetic Acids; Meristem; Models, Biological; Stem Cell Niche; Stem Cells; Cell Differentiation; Developmental Biology, Green Fluorescent Proteins/metabolism, 580, Indoleacetic Acids, gras gene family, Arabidopsis Proteins, Indoleacetic Acids/metabolism, Stem Cells, auxin biosynthesis, Meristem/cytology, Cell Differentiation, Biological, stem cell, stem cells; root development; arabidopsis, arabidopsis, niche, Arabidopsis Proteins/genetics, Stem Cell Niche/drug effects, Gene Expression Regulation, Cell Differentiation/drug effects, transport, Arabidopsis/cytology, scarecrow, Cytokinins/pharmacology, Developmental Biology
570, Cytokinins, root development, growth, Green Fluorescent Proteins, Meristem, Arabidopsis, Models, Biological, Plant/drug effects, arabidopsis root, Models, Gene Expression Regulation, Plant, expression, Stem Cells/cytology, division, thaliana, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Stem Cell Niche, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Arabidopsis; Arabidopsis Proteins; Cytokinins; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Indoleacetic Acids; Meristem; Models, Biological; Stem Cell Niche; Stem Cells; Cell Differentiation; Developmental Biology, Green Fluorescent Proteins/metabolism, 580, Indoleacetic Acids, gras gene family, Arabidopsis Proteins, Indoleacetic Acids/metabolism, Stem Cells, auxin biosynthesis, Meristem/cytology, Cell Differentiation, Biological, stem cell, stem cells; root development; arabidopsis, arabidopsis, niche, Arabidopsis Proteins/genetics, Stem Cell Niche/drug effects, Gene Expression Regulation, Cell Differentiation/drug effects, transport, Arabidopsis/cytology, scarecrow, Cytokinins/pharmacology, Developmental Biology
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