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GEFs on the RhoAd to a Colossal Nucleus

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2012 English Publisher:Elsevier BVJournal:Developmental Cell, volume 22, pages 471-472 (issn: 1534-5807, Copyright policy )
Authors: Shivdasani, Ramesh A.;

doi: 10.1016/j.devcel.2012.02.010

pmid: 22421037

GEFs on the RhoAd to a Colossal Nucleus

Abstract

Cytokinesis in normal cell division requires RhoA-regulated actomyosin contraction of the cleavage furrow; this process is aborted in megakaryocyte endomitosis, leading to polyploidy. In this issue of Developmental Cell, Gao et al. (2012) trace the basis of endomitosis to sequential downregulation of guanine nucleotide exchange factors GEF-H1 and ECT2.

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Developmental Biology

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
hybrid