Tensins: A New Switch in Cell Migration
Copyright policy )Tensins: A New Switch in Cell Migration
Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of beta1 integrin with the actin cytoskeleton in focal adhesions.
- Harvard University United States
Focal Adhesions, Epidermal Growth Factor, Integrin beta1, Microfilament Proteins, Breast Neoplasms, Models, Biological, Erb-b2 Receptor Tyrosine Kinases, Actins, Protein Structure, Tertiary, Cell Movement, Cell Line, Tumor, Tensins, Cell Adhesion, Humans, Protein Isoforms, Female, Cell Adhesion Molecules, Cytoskeleton, Developmental Biology, HeLa Cells
Focal Adhesions, Epidermal Growth Factor, Integrin beta1, Microfilament Proteins, Breast Neoplasms, Models, Biological, Erb-b2 Receptor Tyrosine Kinases, Actins, Protein Structure, Tertiary, Cell Movement, Cell Line, Tumor, Tensins, Cell Adhesion, Humans, Protein Isoforms, Female, Cell Adhesion Molecules, Cytoskeleton, Developmental Biology, HeLa Cells
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