Ubiquitin Ligation without a Ligase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2007 English Publisher:Elsevier BVJournal:Developmental Cell, volume 13, pages 4-6 (issn: 1534-5807,

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Authors: Hochstrasser, Mark;

doi: 10.1016/j.devcel.2007.06.003

pmid: 17609103

Ubiquitin Ligation without a Ligase

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Abstract

Classically, ubiquitination requires three enzymes acting in sequence: E1, E2, and E3. E3 ubiquitin ligases typically provide substrate specificity. An article in Molecular Cell (Hoeller et al., 2007) now describes the E3-independent monoubiquitination of certain proteins. The mechanism has interesting parallels to SUMO ligation.

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Keywords

Ubiquitin, Ubiquitin-Protein Ligases, Humans, Endocytosis, Developmental Biology

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