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Turning off Smads: Identification of a Smad Phosphatase

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2006 English Publisher:Elsevier BVJournal:Developmental Cell, volume 10, pages 412-413 (issn: 1534-5807, Copyright policy )
Authors: Hill, Caroline S.;

doi: 10.1016/j.devcel.2006.03.008

pmid: 16580987

Turning off Smads: Identification of a Smad Phosphatase

Abstract

Although the activation of Smad signaling pathways downstream of TGF-beta superfamily ligands by receptor-mediated Smad phosphorylation is well understood, nothing is known about Smad phosphatases that turn off Smad activity. Recently in Genes & Development, describe pyruvate dehydrogenase phosphatase as a Smad1 phosphatase that functions in Drosophila in the Decapentaplegic pathway and in mammalian cells in the BMP pathway.

Related Organizations
Keywords

Transforming Growth Factor beta, Bone Morphogenetic Proteins, Animals, Smad Proteins, Phosphoric Monoester Hydrolases, Developmental Biology, Signal Transduction

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    popularity
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    		 Average
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Average
Average
Top 10%
hybrid