
pmid: 16256730
The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated kinases (Paks), previously best known for their role in cytoskeletal and transcriptional signaling pathways, also play an important role in centrosome dynamics via phosphorylation and activation of Aurora-A.
Centrosome, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Models, Biological, p21-Activated Kinases, Aurora Kinases, Guanine Nucleotide Exchange Factors, Humans, Cytoskeleton, Rho Guanine Nucleotide Exchange Factors, Developmental Biology, Signal Transduction
Centrosome, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Models, Biological, p21-Activated Kinases, Aurora Kinases, Guanine Nucleotide Exchange Factors, Humans, Cytoskeleton, Rho Guanine Nucleotide Exchange Factors, Developmental Biology, Signal Transduction
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 14 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
