pbX Marks the Spot
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Pbx and Meis proteins act as cofactors to various transcription factors, but their exact functions have been unclear. A report by Berkes et al. in Molecular Cell now demonstrates that Pbx and Meis may penetrate repressive chromatin to mark specific genes for activation.
- University of Massachusetts Medical School United States
Homeodomain Proteins, Transcriptional Activation, Pre-B-Cell Leukemia Transcription Factor 1, Genes, Homeobox, Gene Expression Regulation, Developmental, Neoplasm Proteins, DNA-Binding Proteins, Repressor Proteins, Proto-Oncogene Proteins, Genes, Regulator, Animals, Humans, Myeloid Ecotropic Viral Integration Site 1 Protein, Promoter Regions, Genetic, Developmental Biology, Protein Binding
Homeodomain Proteins, Transcriptional Activation, Pre-B-Cell Leukemia Transcription Factor 1, Genes, Homeobox, Gene Expression Regulation, Developmental, Neoplasm Proteins, DNA-Binding Proteins, Repressor Proteins, Proto-Oncogene Proteins, Genes, Regulator, Animals, Humans, Myeloid Ecotropic Viral Integration Site 1 Protein, Promoter Regions, Genetic, Developmental Biology, Protein Binding
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