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LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas
Article . 2004
License: CC BY NC SA
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Article . 2004
License: CC BY NC SA
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Developmental Brain Research
Article . 2004 . Peer-reviewed
License: Elsevier TDM
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Developmental Brain Research
Article . 2004
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.d...
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Role of allopregnanolone on cerebellar granule cells neurogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2004 Argentina English Publisher:Elsevier BVJournal:Developmental Brain Research, volume 153, pages 13-17 (issn: 0165-3806, Copyright policy )
Authors: Keller, Elizabeth Ana; Zamparini, A.; Borodinsky, L.N.; Gravielle, Maria Clara; Fiszman, Monica Lidia;

doi: 10.1016/j.devbrainres.2004.07.009

pmid: 15464213

handle: 11336/94394

Role of allopregnanolone on cerebellar granule cells neurogenesis

Abstract

The role of allopregnanolone on immature cerebellar granule cells (CGC) proliferation was studied. Allopregnanolone (0.1-1 microM) increased [(3)H]thymidine incorporation and cell number determined by neuronal counting and by an MTT colorimetric assay. The effect of the neurosteroid was completely prevented by preincubation with 10 mM MgCl(2), 10 microM nifedipine, 10 microM picrotoxin or by 50 microM bicuculine. We conclude that ALLO affects cerebellar neurogenesis by increasing calcium influx through voltage-gated calcium channels and GABA(A) receptors activation.

Country
Argentina
Related Organizations
Keywords

GABA A RECEPTOR, Pregnanolone, CALCIUM, NEUROGENESIS, Rats, Sprague-Dawley, Chloride Channels, https://purl.org/becyt/ford/1.6, Cerebellum, Animals, https://purl.org/becyt/ford/1, CEREBELLUM, Cells, Cultured, Cell Proliferation, Neurons, PROLIFERATION, Receptors, GABA-A, Rats, Animals, Newborn, ALLOPREGNANOLONE, Calcium, Steroids, Calcium Channels, Excitatory Amino Acid Antagonists

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 39
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
39
Average
Top 10%
Top 10%
Green