Receptor-like protein tyrosine phosphatase ζ/RPTP β is expressed on tangentially aligned neurons in early mouse neocortex
Copyright policy )Receptor-like protein tyrosine phosphatase ζ/RPTP β is expressed on tangentially aligned neurons in early mouse neocortex
Protein tyrosine phosphatase zeta (PTPzeta)/RPTPbeta is a chondroitin sulfate proteoglycan predominantly expressed in the brain. In this study, we examined immunohistochemical localisation of PTPzeta in the mouse telencephalon from embryonic day 9.5 (E9.5) to E15.5. During E10.5-E12.5, immunoreactivities for PTPzeta are specifically observed on the tangentially aligned neurons at the preplate (PP) of the neocortex, as well as on the neurons at the mantle layer (ML) of the ganglionic eminences (GEs). Likewise, neurons immunoreactive for CR50, a marker for Cajal-Retzius neurons, are aligned from the ML of the ganglionic eminences to the PP of the neocortex and co-express PTPzeta. During E13.5-E15.5, PTPzeta-positive neurons are present at the subplate (SP) as well as at the marginal zone (MZ) of the neocortex. These results indicate that PTPzeta is a useful marker for early-generated neocortical neurons in mice: Cajal-Retzius neurons as well as the subplate neurons.
Neurons, Aging, Calbindins, Extracellular Matrix Proteins, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Cell Adhesion Molecules, Neuronal, Receptor-Like Protein Tyrosine Phosphatases, Class 4, Neocortex, Nerve Tissue Proteins, Embryo, Mammalian, Immunohistochemistry, Mice, Inbred C57BL, Mice, Mice, Neurologic Mutants, Reelin Protein, S100 Calcium Binding Protein G, Bromodeoxyuridine, Proliferating Cell Nuclear Antigen, Animals, Protein Tyrosine Phosphatases
Neurons, Aging, Calbindins, Extracellular Matrix Proteins, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Cell Adhesion Molecules, Neuronal, Receptor-Like Protein Tyrosine Phosphatases, Class 4, Neocortex, Nerve Tissue Proteins, Embryo, Mammalian, Immunohistochemistry, Mice, Inbred C57BL, Mice, Mice, Neurologic Mutants, Reelin Protein, S100 Calcium Binding Protein G, Bromodeoxyuridine, Proliferating Cell Nuclear Antigen, Animals, Protein Tyrosine Phosphatases
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