Rosacea Pathogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2018 English Publisher:Elsevier BVJournal:Dermatologic Clinics, volume 36, pages 81-86 (issn: 0733-8635,

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Authors: Christine S, Ahn; William W, Huang;

doi: 10.1016/j.det.2017.11.001

pmid: 29499802

Rosacea Pathogenesis

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Abstract

Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of cathelicidin and kallikrein 5, Toll-like receptor 2, matrix metalloproteinases, and mast cells within the skin. Their effects are enhanced by the presence of microorganisms and external triggers, such as UV radiation.

Keywords

Transient Receptor Potential Channels, Ultraviolet Rays, Rosacea, Humans

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