Health-related quality of life (QoL) is a patient-reported outcome that describes the impact of the disease in question to all aspects of persons' life, including psychosocial, emotional, physical, and functional impact. As such, health-related QoL is particularly relevant in conditions that have no physical signs and need to rely on patient reports to know whether they are improving or not. Work is beginning in pruritus to develop instruments that can measure pruritus-related QoL. This article reviews the instruments that have been developed and used in pruritus and also reviews the literature regarding the impact of pruritus on QoL.