Homologation of Ugi and Passerini reactions using ynamides

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2018 English Publisher:Elsevier BVJournal:Drug Discovery Today: Technologies, volume 29, pages 43-49 (issn: 1740-6749,

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Authors: Bo, Huang; Sunliang, Cui;

doi: 10.1016/j.ddtec.2018.09.001

pmid: 30471673

Homologation of Ugi and Passerini reactions using ynamides

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Abstract

Being important biological and pharmacological units, β-amino amides and β-acyloxy amides have a privileged position in both academia and industry. Developing a methods to prepare them has gained attention. Ynamides, which possess dual nucleophilic and electrophilic properties, are similar to isonitriles. In this review, usage of ynamides in the single reactant replacement approach of Ugi and Passerini reactions to develop two new multicomponent reactions to get various β-amino amides and β-acyloxy amides is reported.

Related Organizations

Zhejiang Ocean University
China (People's Republic of)

Keywords

Molecular Structure, Chemistry, Pharmaceutical, Chemistry Techniques, Synthetic, Amides

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