Constrained cell penetrating peptides

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2017 English Publisher:Elsevier BVJournal:Drug Discovery Today: Technologies, volume 26, pages 33-42 (issn: 1740-6749,

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Authors: S A, Bode; D W P M, Löwik;

doi: 10.1016/j.ddtec.2017.11.005

pmid: 29249241

Constrained cell penetrating peptides

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Abstract

In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties - one of the big challenges - by means of restraining them. Three different constraining strategies are presented: triggerable activation, backbone rigidification and macrocyclization. Each of these methods have their opportunities in gaining control over CPP activity and selectivity.

Related Organizations

Radboud University Nijmegen
Netherlands

Keywords

Animals, Humans, Cell-Penetrating Peptides, Peptides, Cyclic

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