Drug target identification through systems biology
Copyright policy )Drug target identification through systems biology
To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.
- University of Groningen Netherlands
- University Medical Center Groningen Netherlands
- Vrije Universiteit Amsterdam Netherlands
- University Medical Center Groningen Netherlands
Systems Biology, Computational Biology, Antineoplastic Agents, SDG 3 - Good Health and Well-being, Anti-Infective Agents, Neoplasms, Animals, Humans, Molecular Targeted Therapy
Systems Biology, Computational Biology, Antineoplastic Agents, SDG 3 - Good Health and Well-being, Anti-Infective Agents, Neoplasms, Animals, Humans, Molecular Targeted Therapy
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