Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection
Copyright policy )Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection
The interaction between lens epithelium-derived growth factor (LEDGF/p75) and HIV-1 integrase (IN) is an attractive target for antiviral development because its inhibition blocks HIV replication. Developing novel small molecules that disrupt the LEDGF/p75-IN interaction constitutes a promising new therapeutic strategy for the treatment of HIV. Here we will highlight recent advances in the design and development of small-molecule inhibitors binding to the LEDGF/p75 binding pocket of IN, referred to as LEDGINs.
- Katholieke Universiteit Leuven Belgium
Drug Design, HIV-1, Humans, HIV Infections, HIV Integrase, HIV Integrase Inhibitors, Adaptor Proteins, Signal Transducing, Transcription Factors
Drug Design, HIV-1, Humans, HIV Infections, HIV Integrase, HIV Integrase Inhibitors, Adaptor Proteins, Signal Transducing, Transcription Factors
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