Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors

Name: Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors
Creator: Curtin NJ
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

Curtin NJ

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Drug Discovery Today Disease Models

Article . 2012 . Peer-reviewed

License: Elsevier TDM

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https://dx.doi.org/10.1016/j.d...

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Article . 2012

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Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2012 United Kingdom English Publisher:Elsevier BVJournal:Drug Discovery Today: Disease Models, volume 9, pages e51-e58 (issn: 1740-6757,

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Authors: Curtin NJ;

doi: 10.1016/j.ddmod.2012.01.004

Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors

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Abstract

PARP-1 protects cells from endogenous and therapeutically inflicted DNA damage. PARP inhibitors have been under development since 1980 and first entered clinical trial in 2003. They are an exciting new class of drugs that have the potential to increase the efficacy of anticancer DNA damaging agents and to selectively target cells that have defects in other DNA repair pathways. There are now nine PARP inhibitors undergoing clinical evaluation.

Country

United Kingdom

Related Organizations

Newcastle University
United Kingdom

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