Genetically modified mouse models of cancer invasion and metastasis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2011 English Publisher:Elsevier BVJournal:Drug Discovery Today: Disease Models, volume 8, pages 67-74 (issn: 1740-6757,

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Authors: Rampetsreiter, Paulina; Casanova, Emilio; Eferl, Robert;

doi: 10.1016/j.ddmod.2011.05.003

Genetically modified mouse models of cancer invasion and metastasis

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Abstract

Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investigate mechanisms of cancer invasion and metastasis.

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Keywords

Drug Discovery, Cell Migration and Metastasis Formation, Molecular Medicine

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