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Drug Discovery Today Disease Mechanisms
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Drug Discovery Today Disease Mechanisms
Article . 2012 . Peer-reviewed
License: Elsevier TDM
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Drug Discovery Today Disease Mechanisms
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TSLP: a key regulator of asthma pathogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2012 English Publisher:Elsevier BVJournal:Drug Discovery Today: Disease Mechanisms, volume 9, pages e83-e88 (issn: 1740-6765, Copyright policy )
Authors: Erin E, West; Mohit, Kashyap; Warren J, Leonard;

doi: 10.1016/j.ddmec.2012.09.003

pmid: 24348685

pmc: PMC3859144

TSLP: a key regulator of asthma pathogenesis

Abstract

Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2) inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved in orchestrating the inflammation seen in asthma and other atopic diseases. Early research elucidated the role of TSLP on CD4+ T cells, and recent work has revealed the impact of TSLP on multiple cell types. Furthermore, TSLP plays an important role in the sequential progression of atopic dermatitis to asthma, clarifying the key role of TSLP in the pathogenesis of asthma, a finding with therapeutic implications.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
67
Top 10%
Top 10%
Top 10%
bronze